Anlotinib Hydrochloride

Description

Anlotinib Hydrochloride

Anlotinib Hydrochloride is an oral multi-target tyrosine kinase inhibitor (TKI) used primarily in oncology. It works by blocking several signaling pathways involved in tumor growth and angiogenesis (the formation of new blood vessels that feed tumors).

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Mechanism of Action

Anlotinib inhibits multiple receptor tyrosine kinases, including:

• Vascular endothelial growth factor receptors (VEGFR)
• Platelet-derived growth factor receptors (PDGFR)
• Fibroblast growth factor receptors (FGFR)
• c-Kit and other tumor-related kinases

By blocking these pathways, it:

• Reduces tumor blood supply
• Inhibits tumor cell proliferation
• Suppresses metastasis (spread of cancer)

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Medical Uses

Anlotinib is mainly used in certain cancers, such as:

• Non-small cell lung cancer (NSCLC) (especially as third-line or later treatment in some regions)
• Soft tissue sarcoma
• Investigational use in other solid tumors (clinical trials ongoing)

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Dosage Form

• Oral capsule form
• Usually taken once daily in treatment cycles (e.g., 2 weeks on treatment followed by 1 week off), depending on protocol and physician guidance

(Exact dosing must always be determined by an oncologist based on patient condition.)

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Common Side Effects

• Hypertension (high blood pressure)
• Fatigue
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Diarrhea
• Decreased appetite
• Elevated liver enzymes
• Proteinuria (protein in urine)

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Serious Risks / Warnings

• Severe hypertension requiring monitoring
• Bleeding or hemorrhage risk
• Cardiac effects in susceptible patients
• Liver toxicity
• Thyroid dysfunction (less common)

Regular monitoring of blood pressure, liver function, and urine protein is usually required during treatment.

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Precautions

• Not recommended during pregnancy or breastfeeding
• Use cautiously in patients with cardiovascular disease
• Drug interactions may occur with other anticancer agents or CYP-metabolized drugs

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Summary

Anlotinib hydrochloride is a targeted cancer therapy that works by cutting off tumor blood supply and blocking growth signals. It is not a general chemotherapy drug but a precision oncology treatment used under specialist supervision.